Smoking during pregnancy has been established as a risk to the foetus. Cigarette smoking during pregnancy is the single largest modifiable risk for pregnancy-related morbidity and mortality. As of now, studies have not compared the effects of interventions methods of nicotine replacement therapy and bupropion with regards to risks/benefits to the infant.

Through this study, we aimed to determine and compare the effect of gestational use of bupropion and nicotine replacement therapy on the rate of 1) prematurity, 2) low-birth-weight, and 3) small for gestational age (SGA). These different aspects were studied using data from the Quebec Pregnancy Cohort.

Funding source
Fonds de la Recherche en Santé du Québec (FRSQ), Réseau Québécois de Recherche sur l'Usage des Médicaments (RQRUM), Réseau FRSQ pour le bien-être des enfants, National Cancer Institute of Canada.